Absolutely solid backline CB. He is a must have for any starter, or maybe even ANY Serie A team!
You may look at his passing and feel reluctant to buy him, but really, I haven't got a single bad pass with him in like 10 games (as in error passes, not my terrible gameplay). He also seems to have low agility, but I say: "Embrace it!" Not every player is perfect, but he's damn close!
I play him as right CB in a 4-1-2-1-2 narrow. I use him on the right unlike Kjaer, since he has better passing. I also use Sentinel on him, 81 pace is more than enough personally. An Anchor is also good, but I wouldn't suggest Shadow, you need the strength and jumping for him.
I don't use any special instructions with him, as he has L/W workrate anyway.