I used Marko Arnautovic's Dynamic Duo card in the attached squad as the RST in a 4222 in-game in Division 5 rivals. His instruction set was simply stay forward + False 9 and he was partnered up top by Luuk De Jong's Rulebreaker card which I have also written a review for. I am on old-gen and used Arnautovic with a hunter chem-style to try and give him the ability to make fast runs into the box and latch onto crosses and through balls.
I am not very good at FIFA 23 but I can definitely tell when a player is overpowered this year. With the hunter chem-style and his lengthy accelerate type he is a lethal option for the game this year and only costs about 20k as an SBC right now. He is easy to get chemistry to if you complete Posch's section of the SBC and have a couple of other Serie A players.
His passing, pace, and physical are his best attributes so I would highly recommend him as a second striker or CF instead of as a lone striker because his link-up play is so good. There are not many better options on the game for forwards in Serie A in my opinion and he definitely outperforms players like Immobile or Rashford POTM for me.
Pace + Physical combo
Dribbling + 4* skills
Heading
Passing
Attack Positioning
Outside the foot shot trait
Great penalties
Shooting
Can be inconsistent in bad gameplay
Not very useful if you don't like using the lengthy-style players